15 Endometrial Cancer

The most important prognostic factor is the extent of disease at diagnosis, defined by nodal involvement, tumour invasion beyond the uterus, tumour grading and depth of myometrial infiltration. These different prognostic factors are often correlated to each other. Histological subtyping is also important with a worse prognosis for those histologies which do not correspond to the classical endometrioid adenocarcinoma (4,10,30,43,54,56,82).